PHYTOCHEMICAL AND ANTI-INFLAMMATORY STUDIES ON THE HEXANE EXTRACT OF THE STEM BARK OF STEGANOTAENIA ARALIACEAHOSCHTS (APIACEAE)
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Inflammation has been implicated in virtually all human and animal diseases. It has become the focus of global scientific research, more so, since the currently used anti-inflammatory agents both steroidal and non-steroidal are prone to evoking serious adverse reactions. Steganataeniaaraliacea(Apiaceae)stem bark has been reported to be used in traditional medicine for the treatment of asthma and rheumatism in East Africa. In this study, thehexane extract of the stem bark of the plant was evaluated for its anti-inflammatory property and with a view to isolating bioactive compounds from it.Methods for evaluating macroscopical features and physico-chemical properties were used for the pharmacognostic studies on the stem bark, chromatographic techniques including the thin layer chromatography (TLC) and column chromatography using silica gel were used for the phytochemical studies on the hexane extract of the plant while the anti-inflammatory study was also carried out on the hexane extractusing formalin induced paw oedema in rats. The macroscopical features of the whole stem bark was described as yellowish-green in colour, waxy and short fractured with an aromatic odour while the powdered stem bark was described as brown in colour, aromatic in odour with a sweet bitter taste. The physico-chemical properties of the bark determined include total ash value 10.67%, acid-insoluble ash value 4.00%, water-soluble ash value 1.25%, moisture content 8%, watersoluble extractive value 2.87%, alcohol-soluble extractive value 6.67% and petroleum ethersoluble extractive value 1.27%. The TLC profiling of the hexane extract of the bark showed the presence of steroids/terpenes. The column chromatography of the hexane extract of the stem bark lead to isolation of Compound UF which was characterized using the 1H-NMR spectroscopy and its physical properties. Compound UF was identified as Hentriacotane (C31H64) based on the available spectroscopic data and physical properties which agreed well with those reported in the viii literature. The acute toxicity studies of the hexane extract revealed (LD50) of 282.84mg/kg suggesting the extract is moderately toxic. The effect of the hexane extract on formalin induced paw oedema in rats revealed a dose dependant inhibition of the paw oedema when compared to the reference. The concentrations of the extract at 35, 70 and 140 mg/kg of the extract showed 41%, 42% and 50% inhibition respectively at the peak of the paw oedema which were statistically significant at P<0.05. This indicates a dose dependent anti-inflammatory activity of the extract.
Related Project Materials
PRECISION JOURNALISM AND SENSATIONALISM
ABSTRACT
The broad objective of this study is to critically assess precision...
PROMOTING GLOBAL CITIZENSHIP THROUGH VOCATIONAL TRAINING
Abstract: This research promotes global citizenship through vocational training in Nigeria,...
THE ART OF NATURAL FAMILY PLANNING IN THE LIGHT OF JOHN F. KIPPLEY
STATEMENT OF THE PROBLEM
There is this popular perception that population growth impedes economic devel...
CHALLENGES OF HEALTH APPRAISAL SERVICES
Background Of Study
In Nigeria, the provision of health services for the citizenry is accorded a priori...
DESIGN AND CONSTRUCTION OF AN AUTOMATIC VOLTAGE STABILIZER
ABSTRACT
In the world today, the use of power supply in electroni...
Rhetoric in African Fiction- a Postcolonial Analysis to Ngugi’s A Grain of Wheat, Petals of Blood, Devil on the Cross and Wizard of the Crow
Background to the Study
Rhetoric is the ancient art of argumentation and discourse from primordial Greece to the twentyfirst century. Rhe...
THE ROLE OF ACCOUNTING IN CRYPTOCURRENCY TRANSACTIONS IN FINANCIAL STATEMENTS
Abstract:
This study investigates the role of accounting in cryptocurrency transactions in financial st...
JOB ANALYSIS AND STAFF PERFORMANCE IN PUBLIC COLLEGES OF EDUCATION IN KANO STATE, NIGERIA
ABSTRACT
This study is entitled Job Analysis on Staff Performance in Public Colleges of Education in Kano State, Nigeria. Five objectives...
DESIGN AND IMPLEMENTATION OF PEER TO PEER NETWORK FOR FILE SHARING
CHAPTER ONE
INTRODUCTION
1.1 Background of the Study
File sharing...
TOURISM AND ITS IMPACT IN ALLEVIATING POVERTY IN NIGERIA
EXCERPT FROM THE STUDY
Tourism is travel for pleasure or business; also the theory and practice of t...
