PHYTOCHEMICAL AND ANTI-INFLAMMATORY STUDIES ON THE HEXANE EXTRACT OF THE STEM BARK OF STEGANOTAENIA ARALIACEAHOSCHTS (APIACEAE)
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT
Inflammation has been implicated in virtually all human and animal diseases. It has become the focus of global scientific research, more so, since the currently used anti-inflammatory agents both steroidal and non-steroidal are prone to evoking serious adverse reactions. Steganataeniaaraliacea(Apiaceae)stem bark has been reported to be used in traditional medicine for the treatment of asthma and rheumatism in East Africa. In this study, thehexane extract of the stem bark of the plant was evaluated for its anti-inflammatory property and with a view to isolating bioactive compounds from it.Methods for evaluating macroscopical features and physico-chemical properties were used for the pharmacognostic studies on the stem bark, chromatographic techniques including the thin layer chromatography (TLC) and column chromatography using silica gel were used for the phytochemical studies on the hexane extract of the plant while the anti-inflammatory study was also carried out on the hexane extractusing formalin induced paw oedema in rats. The macroscopical features of the whole stem bark was described as yellowish-green in colour, waxy and short fractured with an aromatic odour while the powdered stem bark was described as brown in colour, aromatic in odour with a sweet bitter taste. The physico-chemical properties of the bark determined include total ash value 10.67%, acid-insoluble ash value 4.00%, water-soluble ash value 1.25%, moisture content 8%, watersoluble extractive value 2.87%, alcohol-soluble extractive value 6.67% and petroleum ethersoluble extractive value 1.27%. The TLC profiling of the hexane extract of the bark showed the presence of steroids/terpenes. The column chromatography of the hexane extract of the stem bark lead to isolation of Compound UF which was characterized using the 1H-NMR spectroscopy and its physical properties. Compound UF was identified as Hentriacotane (C31H64) based on the available spectroscopic data and physical properties which agreed well with those reported in the viii literature. The acute toxicity studies of the hexane extract revealed (LD50) of 282.84mg/kg suggesting the extract is moderately toxic. The effect of the hexane extract on formalin induced paw oedema in rats revealed a dose dependant inhibition of the paw oedema when compared to the reference. The concentrations of the extract at 35, 70 and 140 mg/kg of the extract showed 41%, 42% and 50% inhibition respectively at the peak of the paw oedema which were statistically significant at P<0.05. This indicates a dose dependent anti-inflammatory activity of the extract.
Related Project Materials
An examination of the role of translation in bridging dialectal differences in Yoruba language
Background of the study
The Yoruba language is marked by a rich tapestry of dialects, each reflecting dis...
EFFECT OF COVID-19 PANDEMIC ON SOCIAL RELATIONSHIP AMONG STUDENTS OF NASARAWA STATE UNIVERSITY, KEFFI.
BACKGROUND OF THE STUDY
The coronavirus disease of 2019 (COVID-19) pandemic gripped the world with a sh...
An evaluation of the role of traditional rulers in the preservation of indigenous languages in Ezza South Local Government Area, Ebonyi State.
Background of the Study:
Traditional rulers have historically been custodians of cultural heritage, signif...
The Effect of Urban Slum Conditions on Human Rights in Jalingo, Taraba State
Background of the Study
Urban slums are areas characterized by overcrowded living conditions, inadequat...
SANITATION PRACTICES AND IT'S IMPLICATION ON THE HEALTH OF UNDERGRADUATE STUDENTS OF KWARA STATE UNIVERSITY, MALETE
BACKGROUND OF THE STUDY
When it comes to preserving people's health, sanitation refers to both the...
A COMPARATIVE ANALYSIS OF THE ENFORCEMENT OF FOREIGN JUDGMENT IN NIGERIA AND UNITED KINGDON: A CASE FOR CYBER JURISDICTION
Abstract
Under Private International Law, enforcement of foreign judgment or its recognition is the whole mark of every proceeding. Witho...
The effect of skeletal remains analysis in solving missing person cases in Akure South Local Government Area, Ondo State
Background of the study:
Skeletal remains analysis plays a pivotal role in resolving missing person cases...
An examination of the relationship between foreign exchange reserves and economic stability in Nigeria: A study of the CBN (2000–2020).
Background of the Study:
Foreign exchange reserves serve as a buffer against external economic shocks and play a vital role in ensuring a...
AN APPRAISAL OF THE JURISDICTION AND POWERS OF THE NATIONAL INDUSTRIAL COURT OF NIGERIA
ABSTRACT
Generally, jurisdiction is a term of comprehensive import embracing every kind of judicial action. The fundamental nature of jur...
The effect of public‐private partnerships on the development of school sports in Ilorin West Local Government Area, Kwara State
Background of the Study
Public–private partnerships (PPPs) have increasingly emerged as a pivotal model for financing and managing...
